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Tumore di Wilms: gli sforzi per individuare le recidive nei primi due anni dopo la malattia
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#1 Inviato : lunedì 10 settembre 2018 7.52.43(UTC)
Rank: Administration
Messaggi: 5.655

TUMORE DI WILMS: GLI SFORZI PER INDIVIDUARE LE RECIDIVE NEI PRIMI DUE ANNI DOPO LA MALATTIA


Secondo i risultati di un'analisi retrospettiva pubblicata su Lancet Oncology volta a evidenziare le strategie più efficaci per una migliore gestione del follow-up del tumore di Wilms, i controlli per le recidive nel follow-up della patologia andrebbero concentrati nei primi due anni dopo il tumore. «Questi dati ci portano per la prima volta a focalizzare l'utilità degli esami di controllo nei primi due anni, quando tra l'altro un riscontro precoce della recidiva ha una prognosi migliore,...

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Daniela Pelotti
#2 Inviato : lunedì 10 settembre 2018 7.52.45(UTC)
Rank: Advanced Member
Messaggi: 50
Pediatr Hematol Oncol. 2017 Nov;34(8):478-482. doi: 10.1080/08880018.2017.1404171. Epub 2017 Dec 8. Coincidence of celiac disease with nongastrointestinal tumors in children. Naderi M1, Shahramian I2, Delaramnasab M3, Bazi A3. Author information Abstract The association of celiac disease (CD) with cancers of gastrointestinal origin has been noted. However, coincidence of CD with nongastrointestinal neoplasms is an unusual event. Here we present five children with concurrent CD and nongastrointestinal neoplasms. All of the patients had positive serologic results for anti-tTG antibodies. Histological investigation of intestinal mucosa showed inflammation (Marsh score = 2) in all the patients. Two of these patients represented with germ cell malignancies. One patient had Wilms' tumor. To our knowledge, these are the first reports of coincidence of these two cancers with CD in children. From the remaining two patients, one was diagnosed with acute lymphoblastic leukemia, and the other with astrocytoma. The diagnosis of malignancy preceded CD diagnosis in all the patients (mean ages of cancer and CD diagnosis of 1.8 and 5.4 years old, respectively). Whether malignancy can promote immune deregulation and predispose to CD is uncertain. On the other hand, undiagnosed celiac may be a risk factor for cancer. Our results suggest a potential association of CD with malignancy nature of CD, however, occurrence of CD may be influenced by various intrinsic and extrinsic factors. There are few reports noting CD as a paraneoplastic condition. Further investigations are necessitated to stablish such relationship.
Daniela Pelotti
#3 Inviato : lunedì 10 settembre 2018 7.52.48(UTC)
Rank: Advanced Member
Messaggi: 50
Pediatr Hematol Oncol. 2017 Nov;34(8):478-482. doi: 10.1080/08880018.2017.1404171. Epub 2017 Dec 8. Coincidence of celiac disease with nongastrointestinal tumors in children. Naderi M1, Shahramian I2, Delaramnasab M3, Bazi A3. Author information Abstract The association of celiac disease (CD) with cancers of gastrointestinal origin has been noted. However, coincidence of CD with nongastrointestinal neoplasms is an unusual event. Here we present five children with concurrent CD and nongastrointestinal neoplasms. All of the patients had positive serologic results for anti-tTG antibodies. Histological investigation of intestinal mucosa showed inflammation (Marsh score = 2) in all the patients. Two of these patients represented with germ cell malignancies. One patient had Wilms' tumor. To our knowledge, these are the first reports of coincidence of these two cancers with CD in children. From the remaining two patients, one was diagnosed with acute lymphoblastic leukemia, and the other with astrocytoma. The diagnosis of malignancy preceded CD diagnosis in all the patients (mean ages of cancer and CD diagnosis of 1.8 and 5.4 years old, respectively). Whether malignancy can promote immune deregulation and predispose to CD is uncertain. On the other hand, undiagnosed celiac may be a risk factor for cancer. Our results suggest a potential association of CD with malignancy nature of CD, however, occurrence of CD may be influenced by various intrinsic and extrinsic factors. There are few reports noting CD as a paraneoplastic condition. Further investigations are necessitated to stablish such relationship.
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